Endocrine Abstracts

Introduction: 17- α hydroxylase deficiency, an autosomal recessive disorder, is a rare cause of Congenital Adrenal Hyperplasia (CAH). The disease is usally diagnosed during infancy and childhood. We present here a rare case of an adult woman with 17-α hydroxylase deficiency diagnosed for first time in adulthood.Presentation: A 49 year old woman, with no previous medical history came to the emergency department of our hospital unconscious with G...

Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from neuroendocrine cells in the endocrine and central nervous system, the natural history of which remains inadequately understood. Large epidemiological studies are gradually emerging from different countries worldwide, which contribute to the establishment of a spherical view about these tumors. The purpose of this study is to evaluate the epidemiological, clinical and pathological cha...

Background: Although primary hyperparathyroidism (PHPT) has been associated with diabetes mellitus (DM), the etiological link is not clear and the effect of parathyroidectomy is controversial.The aim of this observational study was to investigate the metabolic link between calciotropic hormones and glucose metabolism in PHPT patients before and after parathyroidectomy.Methods: Twenty-four consecutive patients with PHPT (Group-A) without DM were included ...

Introduction: Infectious diseases of the central nervous system (CNS) have been associated with hypopituitarism which relates to the severity, the localization and the cause of the infection. We present here a case of a CNS abscess and hormone deficiencies. A 53 years old man referred to the emergency department of our hospital with high fever and confusion and a 3 day history of weakness and anorexia. On clinical examination he was febrile (38.4oC), disoriented in ...

Introduction: Noonan syndrome is a genetic disorder that usually occurs on a sporadic basis (de novo mutuations) or with autosomal dominant inheritance. Patients present with dysmorphic facial features, cardiac disorders and short stature. Delay of puberty can also be noted. We present here an adult case of Noonan syndrome.Presentation: A 25 years old male presented to our department with low stature, decreased libido and absence of any secondary sexual ...

Introduction: Gonadal dysgenesis is a rare cause of primary amenorrhoea, and refers to a number of conditions in which gonadal development is abnormal leading to streak or hypoplastic gonads. We present a rare case of a girl with primary amenorrhea, tall stature, gonadal dysgenesis and karyotype 46,XX. A 15 years old girl with primary amenorrhoea referred to our department for futher investigation. On clinical examination she was tall (height 1.74 m), her weight was 76 kg and ...

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

Aim: Well-differentiated thyroid cancer (TC) comprises the most common endocrine malignancy, featuring very good prognosis and 5-year survival rate of nearly 100% after total thyroidectomy. However, the prevalence of incidental thyroid microcarcinoma (mITC) is continuously rising during the last decade. One obvious reason is the high prevalence of total thyroidectomy (TT) as the preferred operation for otherwise benign nodular or diffuse thyroid diseases. The current retrospec...

Aim: Thyroid cancer (TC) is the most common endocrine malignancy, presenting a rising incidence during the last decade, due to continuously rising prevalence of incidental thyroid microcarcinomas (mITCs; ≤1 cm) in benign thyroid diseases treated with total thyroidectomy (TT). Solitary thyroid nodule (STN) is a thyroid condition, which remains under debate regarding the extent of thyroidectomy needed (total or near-total thyroidectomy vs unilateral lobectomy). Objective o...

Objectives: • PCOS is defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders.• Women are exposed to increased risk for cardiovascular disease, hypertension, type 2 diabetes mellitus and other metabolic complications• Cardiovascular disease (CVD) is one of the most common cause of mortality wor...